Research models explain role of genes in diseases

Dr. Jingky P. Lozano-Kühne, Balik Scientist Program (BSP) Awardee of the Department of Science and Technology (DOST), talked about modelling methods detecting effects of genes on complex diseases in her Exit Report Presentation held at the College of Public Health Auditorium, University of the Philippines – Manila last 23 June 2016.

Dr. Jingky Lozano-Kuhne, UP Manila Visiting Professor under the DOST Balik Scientist Program discusses on models detecting effects of genes in diseases on her public lecture entitled “Modelling Methods for Detecting Genetic Effects” last 23 June 2016 at the College of Public Health Auditorium, University of the Philippines – Manila


In her talk, Dr. Lozano-Kühne said that while genes may indeed be involved in the formation of diseases, it is difficult to identify if a particular gene plays a role, especially in complex diseases (e.g. cardiovascular ailments).  “In complex diseases, it’s a little bit complicated because there are other factors involved not only the gene but there can be environmental factors, lifestyle… epistasis, or the interaction between genes,” she stated.

This concern can be addressed through the help of modelling methods. Through models, it would be easier to understand the relationships between the genes considering other factors affecting subject, Lozano-Kühne added. A more popular modelling method in genetic research is the animal method where the genes of an animal subject are regulated to identify the effect on its characteristics. Dr. Lozano-Kühne also discussed the use of statistical models in genetic studies. In using this model, it is important to identify the desired output of the research. Output will determine what particular statistical approach a researcher may apply to get genetic conclusions. Statistical methods may determine the role of the parents’ gene in the disease of their child or if who among the children is more at risk of getting the disease, among others. Empirical applications of the models were identified in defining the relationship between the gene and its effect on coronary artery calcification and in cases of lung cancer in the young.

Orientation Booklet for Filipinos in Germany 2016, released March 2016

Dr. Lozano-Kühne also co-authors the “Orientation Booklet for Filipinos in Germany 2016,” a guide for visiting Filipinos, migrants, and new residents in Germany, where the DOST Balik Scientist Program was recommended to interested balikbayan scientists and professionals

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