TECHNOLOGY GENERATOR

Alvin B. Caballes, MD, MDE, MPP
University of the Philippines Manila

THE PROBLEM

Gastroschisis is a life-threatening congenital condition where a defect in the abdominal wall
causes the intestines to protrude outside the body without protective covering. In low- and
middle-income countries (LMICs) like the Philippines, the mortality rate can reach up to 100%
due to limited access to specialized medical devices and care. The preformed silo bags and
related assistive devices used for staged reduction and delayed closure are expensive and
largely unavailable locally. As a result, newborns affected by this condition are often left
without appropriate interventions, resulting in poor outcomes.

THE SOLUTION

This project introduces a locally designed and fabricated assistive device which is expandable and reusable for the staged reduction and closure of pediatric abdominal wall defects, particularly gastroschisis. It aims to provide a cost-effective, accessible alternative using materials and methods suitable for local production. The device comprises a biocompatible reduction component, at least one pliable ring, and a compatible 3D-printed support structure, with provisions for incorporating sensors to monitor the intra-abdominal pressure and temperature. A redesigned abdominopelvic phantom has also been developed to support testing and refinement of the prototype.

TECHNOLOGY DEVELOPMENT STATUS

Currently in the advanced prototyping stage, the project has produced 50% and 100% scale prototypes through iterative fabrication trials. Mandrel and silicone molding techniques were refined across multiple trials to optimize uniformity and reduce defects. A functional prototype (Trial 8F) has successfully been assembled with the 3D-printed component and tested on a simulated anatomical model. Pending procurement of biocompatible material, the final molding technique and in-vitro and animal testing are scheduled. A patent has been filed and is under examination.

CURRENT NEEDS

To advance the device toward clinical use, the project seeks partners for the fabrication of mandrels through CNC machining and the procurement of biocompatible material for final testing. Collaboration with hospitals is needed for clinical validation, while partnerships with local biomedical manufacturers will support production and distribution. Policy advocates and healthcare stakeholders are also invited to help integrate the device into national systems and explore sustainable funding options.

CONTACT DETAILS

Technology Transfer and Business Development Office
University of the Philippines Manila
2/F Main Building, Joaquin Gonzales Compound
Ermita, Manila
ttbdo.upm@up.edu.ph