Annual Report 2002

{mospagebreak title=Directory of Officials}

DIRECTORY OF OFFICIALS

Governing Council

Chairman

Dr. Estrella F. Alabastro
Secretary
Department of Science and Technology

Vice Chairman

Dr. Manuel A. Dayrit
Secretary
Department of Health

Ex Officio Members

Ms. Elsa M. Bayani
Executive Director
National Nutrition Council

Dr. Alfredo T. Ramirez
(November 1999 - 2002)
Chancellor
University of the Philippines
Manila

Dr. Gemiliano D. Aligui
Executive Director
Philippine Council for Health Research and Development

Members

Dr. Ernesto O. Domingo
Fellow
Philippine Society of Gastroenterology

Dr. Abraham F. Pascual
President
Pascual Laboratories, Inc.

Dr. Josefina L. Poblete
Dean, College of Medicine
Cebu Institute of Medicine

Dr. Warlito C. Vicente
Dean, College of Medicine
Davao Medical School Foundation

CHED Representative

Dr. Rodolfo de Guzman
Chairman
Technical Panel for Health
Profession Education
Commission on Higher Education

Technical Directors

Dr. Jane C. Baltazar
Dr. Bonifacio C. Dazo
Dr. Adriano V. Laudico
Dr. Fernando S. Sanchez, Jr.
Dr. Wilfred Tiu
Dr. Victor C. Valenzuela

Executive Director

Dr. Gemiliano D. Aligui
Tel. no. 837-2942
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Division Heads

Ms. Emelita N. de Castro
Finance and Administrative Division
Tel. No. 837-7536
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Dr. Alan B. Feranil
Research Management and
Development Division
Tel. No. 837-7535
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Ms. Teresita O. Laguimon
Officer-In-Charge
Human Resources and Institution
Development Division
Tel. No. 837-7537
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Ms. Merlita M. Opeña
Research Information, Communication
and Utilization Division
Tel. No. 837-7537
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{mospagebreak title=Message from the Secretary}

 

I commend the Philippine Council for Health
Research and Development, as it celebrated its 20th
year, for its unwavering commitment to advance the cause of health research and development in the Philippines despite seemingly tall odds.

PCHRD's pioneering work and leadership in health R and D has been reaffirmed by its partners. The ongoing work of establishing the Philippine National Health Research System, in line with the global movements in health research, places PCHRD in a lead role in the crafting of a unified research agenda, to optimize the use and ensure equity of distribution of scarce resources.

As evidenced by this Annual Report, PCHRD continues to support research projects, whose outputs are transformed into tangible products and services--from fortified foods, drugs from medicinal plants, to clinical practice guidelines--to benefit the Filipinos.

PCHRD's capacity-building program, among others, its twinning program, helps develop a secure human resource base that will sustain the supply of health research knowledge, which can, in turn, be translated into policies and actions for better health.

The knowledge bases created from PCHRD's work and its programs are being purposively communicated to its partners and beneficiaries in the health and allied sectors. PCHRD has been a trendsetter in online information resource building, dissemination and searching services, notably, its HERDIN, e-Health and telecenter initiatives.

As we continue to witness everyday miracles in the health sciences, I am confident that PCHRD will deliver on its commitment to make research a significant contributor to social equity and better quality of life.



ESTRELLA F. ALABASTRO
DOST Secretary

{mospagebreak title=Message from the Executive Director}


It pioneer Robert Noyce put it succinctly when he cautioned "Do not be encumbered by past history. Go off and do something wonderful." Indeed, while we are proud of what the PCHRD has accomplished in the past twenty years, we are also aware that innumerable challenges are still waiting to be hurdled in the new century.

In an age where the primary resource is knowledge, we all the more commit ourselves to our mission to promote research
and the effective use of technology as requisites for the development of healthcare services in the country.

Thus, in 2002, we continued to build the human resource base for health research by encouraging new research advocates from regional sister institutions through the Twinning Project and other scholarship opportunities. We sought to enclose more communities into the mainstream of the digital economy through the Multipurpose Community Telecenter Project
e-Health, HERDIN, and digital library initiatives. Moreover, we continued to build on traditional products and ideas, from herbal preparations to food fortification, while at the same time actively supporting new avenues for knowledge generation through the AMOR and ADONIS projects.

In 2003, we are aiming for something bigger: the consolidation of the various initiatives in the country to come up with a unified Health Research Agenda together with our partner agencies, towards a Philippine National health Reasearch System.

Needless to say, coming up with one vision, one goal, for the Philippine health research community will entail a lot of work. But as Noyce said, we just need to pool our resources together to be able to do something wonderful.



GEMILIANO D. ALIGUI, M.D., MPH, PhD
Executive Director

{mospagebreak title=Highlights}

HIGHLIGHTS

PCHRD @ 20: Assessing bioinformatics' role in health biotechnology




Turning 20, the Council commits to advancing health research in our country by opening the gateway for health biotechnology. The celebration theme, "Bioinformatics: Advancing Biotechnology, Securing our People's Health," provided an opportunity to discuss and recognize the potentials of bioinformatics as a promising tool in speeding the way we do research in biotechnology and the life sciences. This development impacts research in vaccine, gene targeting technology, genomics and its related fields, hence, calls for new strategies for supporting and networking research in health biotechnology.

Setting up the Philippine Health Research System

A series of focus group discussions, a workshop, literature search, and an assessment of secondary documents was conducted by PCHRD, with the Health Policy Development and Planning Bureau (HPDPB)-Research Unit of the Department of Health (DOH) and the National Institutes of Health (NIH) to assess the Philippine National Health Research System (PNHRS).

Key findings of the assessment indicated that while there have been efforts to use local researches for policy and program development, the Philippines still need to improve on packaging its research results to reach their target audiences. Appropriate indicators and a unified system of evaluation and monitoring are also needed to measure gains in health.

The PCHRD, building on existing frameworks, was identified to take the lead in the PNHRS development in the country.

The PNHRS, anchored on the principles of Essential National Health Research (ENHR) on inclusiveness, participation, quality, equity, efficiency and effectiveness will promote, facilitate, synergize and coordinate activities to come up with a coordinated and coherent research agenda which connect to, and converge with, the wider health, economic, political, educational and S&T systems of the country.

{mospagebreak title=Health Gains from Research Investments }
I. Health Gains from Research Investments

Research continue to play a vital role in changing our understanding and approaches in disease prevention and treatment, drug and vaccine development and health care strategies.

To this end, PCHRD continually updates itself to ensure it supports priority research programs that will most likely improve the health status of the country.

For this year, we focused on research and scholarship grants for researchers venturing on natural health products; diagnosis, prevention and control of priority diseases; functional foods and nutraceuticals; drugs and vaccines for local needs; telemedicine and bioinformatics applications.

COCONUT FLOUR, your healthy source of dietary fiber

In September 2002, another product from coconut opened economic opportunity for the country when the Food and Nutrition Research Institute (FNRI) found that coconut flour is a good source of dietary fiber and can be comparable to oat bran and flaxseed known to prevent risk for chronic diseases.

This is the first reported study conducted on the physiological functions of dietary fiber from coconut by-product, coconut flour from 'sapal'' or coconut residue thus, giving us the economic edge for increasing production of our coconut and coconut-by-products.

LOCAL SEAWEED EXTRACT, prevents heart disease

In May 2002, carrageenan was found to lower lipid and high cholesterol levels. This was based on the PCHRD funded study on "Metabolic effects of Local Seaweed Extracts II: Lipid and Cholesterol Levels" conducted by the College of Home Economics in UP Diliman. Results showed that carageenan, when added to foods and taken for 8 weeks at 40-50 grams dietary daily fiber intake, exerts lipid-lowering and hypocholesterolemic (cholesterol lowering) effects.

Carrageenan is a local seaweed extract commonly used as thickening, stabilizing or emulsifying agent in dairy products, reprocessed meats and a variety of other foods.

Translating quality care through CLINICAL PRACTICE GUIDELINES

On Management of Breast Cancer

To establish a more consistent clinical practice on the management of breast cancer, we collaborated with the Philippine College of Surgeons and the UP College of Medicine to develop the second Clinical Practice Guidelines (CPG) project.

Both online and manual literature search was conducted based on the clinical questions outlined for each of the clinical stages of breast cancer. Search results were compiled, analyzed and classified according to levels of evidence and recommendations were drawn-up for each stage of breast cancer: 1) Early Breast Cancer and 2) Locally Advanced and Metastatic Breast Cancer.

On Periodic Health Examinations

At present, a study is being conducted by the Philippine College of Physicians to develop a National Guideline that will specify the necessary clinical tests to be included in periodic health examinations. These guidelines not only prevent the quality of health service from depreciating, it will also help HMO's, physicians and hospitals in determining the screening tests needed in a cost-effective manner.

The national guidelines on periodic health examinations for Filipino patients will address screening for cardiovascular diseases, neoplastic diseases, mental disorders and substance abuse, musculoskeletal diseases, congenital diseases, prenatal disorders, infectious diseases, metabolic, environmental and renal disorders, vision and hearing disorders and childhood and developmental disorders.

Developing drugs from Indigenous Resources

Continuing studies on priority Philippine medicinal plants are being conducted to validate claims on its therapeutic effect and safety; verify its pharmacologic, toxicologic, mutagenicity and anti-mutagenicity properties; and to establish quality standard procedures for dosage formulations for use in the treatment of priority diseases and/or disorders.

The DOST-funded research program, "Antibody Biotechnology and Liposome Drug Delivery Technology for Experimental Therapeutics of Breast Cancer" (AMOR Project) also continues its research work in developing drugs for breast cancer using antibody biotechnology and liposome drug delivery while harnessing the potential of marine and terrestrial resources.

{mospagebreak title=II. Bringing Research Results to the Market }

II. Bringing Research Results to the Market

Health technologies available for takers

In December 2002, the technology transfer documents containing the details of the production of the Yerba Buena tablet was completed. Interested takers may adopt the production technology through a non-exclusive licensing agreement. They only need to communicate directly with the Office of the Executive Director.

The Yerba Buena tablet was found comparable with paracetamol in relieving pains among patients with moderate to sever post-dental extraction, post-circumcision, post-episiotomy and post-tissue biopsy pain.

Also, the production technology for the Lagundi tablet and syrup (remedy for cough), Sambong tablet (diuretic, for urolithiasis) and Akapulko Lotion (antifungal), though transferred to local drug manufacturers, are still open to interested takers in the industry.

Creating value out of Patent-Free Drugs

In August 15, 2002, a DOST-Industry Dialogue convened by PCHRD in coordination with the Technology Applications and Promotions Institute (TAPI) to discuss options in developing value-added products from patent-free drugs among industry partners and researchers in drug manufacturing sector. Responding to the need for technological innovation from off-patent drugs, DOST's proposal for industry collaboration was presented---the development of innovative products, capability building of the local drug manufacturers and other collaborative effort with the industry and the academe.

{mospagebreak title=III. Strengthening Research Information Services
}

III. Strengthening Research Information Services

HERDIN online for Free

PCHRD continues to generate information goods for the knowledge-driven society by developing specialty databases and web-based resources.

In August 2002, HERDIN online databases were made available for free. This drastically increased our number of subscribers to 400% in just four months.

As the needs of our researchers for updated health research abstracts and full text articles increased, we began developing the HERDIN (Health Research Development Information Network) CDROM Version 2, which is scheduled for release on June, 2003. Aside from a totally new look and feel interface, the 2nd version of HERDIN CD contains 4,000 new bibliographic health research records and over 1,000 full-text articles.

Locating Health Journals Online

For better access of information by health researchers, we supported a project that puts online the National Union List of Medical and Health Periodicals of the Medical and Health Librarians Association of the Philippines (MAHLAP). Now on its third volume, this web-based version of the National Union List of Medical and Health Periodicals (1996-2002) is expected to enhance resource sharing among libraries making journal holdings easily accessible and available-providing information from which specific libraries the journals are located.

Led by MAHLAP's President Ms. Adaway F. Racal, the project is presently encoding the lists of serial collections gathered from MAHLAP members. The launching of the evaluated library software and the Online MAHLAP Directory and Union List is scheduled on February 2003, during MAHLAP's 15th year anniversary, and is expected to be available on the MAHLAP website (http://www.pchrd.dost.gov.ph/mahlap/) by April 2003.

E-Health Presents: Specialty Database and Internet Resources on People-Managed Health (PMH) and Reproductive Health

As part of the e-Health portal, the People-Managed Health (PMH) database-a community health research initiative of the Institute of Philippine Culture (IPC) of the Ateneo de Manila University, makes available in the Internet a learning database on people-managed health. This database reflected the advanced experiences in primary health care programs and community health in the Philippines. At present, the PMH database contains bibliographic entries and abstracts of 522 titles, 447 published and 75 unpublished articles.

PCHRD also supported the development of a specialty database and internet resources on Reproductive Health, a project headed by Dr. Mario Festin. This information gateway provides Philippine information on family planning, maternal and child health and nutrition, reproductive tract infections (HIV/AIDS and STDs), sexuality and sexual health, obstetrics and gynecology, men's and adolescents' reproductive health, violence against women, and sexual disorders. It also links with information resources existing within and outside the country.

Building the E-Health Digital Library

The "e-Health Digital Library" project aims to 'virtually' merge the collection and services of national and regional libraries from the academe and other institutions from the public and private sector in the Philippines-promoting sharing of library resources and piloting a strategy for accessing important international electronic health journals, in full text.

A survey which assessed the use and potentials of electronic resources and services showed that libraries play an important role in accessing information on the Net; and that most researchers would like libraries to go 100% online. Online searching enables researchers to retrieve up-to-date information more easily and gives them wider information choices.

Utilizing ICT Tools for Community Development

Responding to rural communities' information and communication needs through the use of ICT tools, we facilitated the development of an interactive and comprehensive website for our Multipurpose Community Telecenters (MCT) project (www.barangayconnect.ph). The website contains relevant information about the project, content and ICT-based applications on health, education, agriculture/fisheries/natural resources, and rural enterprise development developed by the project partners and the communities themselves.

Each of the four MCT barangay is in the process of developing their own website. The Agusan del Norte Community Telecenter launched in January 2002 its "Hisgot-Hisgot sa Barangay." The website, http://caraga.dost.gov.ph/~mctagusan/,
served as the community's online newsletter, which enabled the communities to write news articles, post announcements, ask queries, and contribute articles on health, education, agriculture, livelihood, and business.

Empowering Rural Communities through MCT

Activities that aim to enhance community mobilization in the two MCT sites in Lanao del Norte were undertaken. To date, several purok assemblies were conducted to discuss various concerns such as information campaign for the MCT project, identification of sectoral groups, appointment of sectoral representatives, and enumeration of information needs by each sector.


A core group and people's organization in each of the two barangays were formed. MCT volunteers from each purok were identified where skill assessment of the identified volunteers was conducted. MCT Board members were also identified. Rules and regulations in using MCT facilities were formulated. Trainer's training for MCT volunteers on computer literacy, effective teaching, and values formation as well as computer literacy training for teachers were also held.

The above activities proved to be not only helpful in promoting project awareness among community members but also in eliciting active community participation.

Communicating Research through Techno-Fairs

PCHRD participated in five Science and Technology Fairs held in the regions in 2002.

This gave us an opportunity to promote economic opportunities from indigenous herbal products and encourage both government and private sectors to support and develop herbal products and applications in the country.

For these events, we showcased six herbal products among which two are already out in the market (Lagundi and Sambong), two undergoing phase III clinical trials (Tsaang-Gubat and Ampalaya) and two completed products ready for commercialization (Akapulko lotion and Tsaang-gubat). We also featured the PhilMedPlants Research Database, one of the e-Health specialty database projects, where researchers can access abstracts and full-text articles online.

The exhibits were displayed at Quezon City, Olongapo City, Ormoc City, Baguio City and Batac, Ilocos Norte. Local government officials, academicians, researchers, students and employees from various government and private sector organizations who were able to see the exhibits were given a venue for discussion and clarification especially about common misconceptions on herbal drugs that are commercially available nowadays.


Winners of the 13th Scientific Poster Exhibit and their entries
July 8-12, 2002



PROFESSIONAL CATEGORY

Grand Prize:

Trinidad P. Trinidad, PhD, Divinagracia H. Valdez, Aida C. Mallilin, Faridah C. Askali, Joan C. Castillo, Anacleta S. Loyola, Dina B. Masa, Angelica S. Maglaya, Modesto T. Chua, PhD.
Food and Nutrition Research Institute

"Dietary Fiber in Coconut Flour: A Functional Food"

STUDENT CATEGORY

Grand Prize:

Lilibeth A. Sales, L.A., OTRP, Alma C. Chang, Ariel L. Paredes, Ferleo C. Pasia, Jan Claire Rabang, Karen C. Tan and Michael Yutadco
College of Rehabilitation Sciences, University of Santo Tomas

"iSee: A Computerized Screening Tool for Visual Perceptual Skills"

BEST PACKAGED TECHNOLOGY

Lilibeth A. Sales, L.A., OTRP, Alma C. Chang, Ariel L. Paredes, Ferleo C. Pasia, Jan Claire Rabang, Karen C. Tan and Michael Yutadco
College of Rehabilitation Sciences, University of Santo Tomas

"iSee: A Computerized Screening Tool for Visual Perceptual Skills"


Disseminating Health Information Online

For our health information dissemination activities, PCHRD continued to reach out to the health community and the general public through press conferences, symposia, seminars, health forums and exhibits to ensure that Filipinos reap the returns from public investment in health research and development.

This year, we held 11 exhibits, 13 press conferences, forums and symposia; monitored over 25 press releases; and disseminated more than 32,783 copies of print materials to research institutions in Metro Manila and in the regions.

We also expanded our feedback
gathering system by converting the succeeding issues of the Philippine Health Research for Development Newsletter to a web version accessed by logging at www.pchrd.dost.gov.ph/NEWSLETTER. This bi-monthly newsletter still carries-over much of the publication's content in health and health R&D sections where readers can subscribe online for news updates.

EXHIBITS / TECHNOLOGY FAIRS

PCHRD Anniversary & Bioinformatics
Manila Midtown Hotel
15 March 2002

APMC exhibit
Manila Midtown
11-12 April 2002

e-Gobyerno
SM Megamall
7-8 June 2002

Independence Day Exhibit
Philippine Tourism Authority
9-12 June 2002

13th Annual DOST S&T Fair
PHILVOLCS
8-12 July 2002

13th PCHRD Scientific Poster Exhibit
UP-PGH
8-12 July 2002

Regional Science and Technology Fair
Olongapo City Convention Center
21-26 July 2002

3rd Visayas Cluster Science and Technology
Ormoc City
8-12 August 2002

Cordillera Science and Technology
Baguio National High School
1-7 September 2002

PHILAAS Convention
University of Sto. Tomas
13-18 September 2002

Northern Luzon S & T Clusters
Mariano Marcos State University
Batac, Ilocos Norte
30 September - 5 October 2002



PRESS CONFERENCES and SCIENTIFIC FORUMS

Presentation of research fellowship project entitled, "Hemophilia: Molecular Approach"
University of Sto. Tomas-Research Center for Natural Sciences (UST-RCNS)
January 26, 2002

Presentation of 3 ongoing projects of FEU-SLU
St. Louis University (SLU), Baguio City
22 February 2002

Newborn Screening - Save the Babies from
Mental Retardation and Death
University of the Philippines-College of Public Health (UP-CPH) Conference Room
1 March 2002

Substance Abuse among Street Children
Press Conference
National Institutes of Health (NIH)
5 April 2002

Forum on Substance Abuse among
Street Children
National Institutes of Health (NIH)
5 April 2002

Cancer Pain Management and Treatment
Press Conference
National Institutes of Health (NIH)
27 June 2002

Presentation of Outstanding Health
Research Award (OHRA)
PHIVOLCS
10 July 2002

Safety of Food Products Derived from
Modern Biotechnology
Press Conference
Philippine Trade Training Center (PTTC)
24 September 2002

Annual Health Research Forum for
Completed Projects
RHRDF-7, Cebu City
21 November 2002

Research Forum-Twinning Project
St. Louis University, Baguio City
30 November 2002

Nutritional and Health benefits of coconut flour
Press Conference
National Institutes of Health (NIH)
5 December 2002
Health Research Forum
Asia Stars Hotel, Tacloban City
6 December 2002

PRESS RELEASES
[Radio, television and print media]

PCHRD Policies, Thrusts, Direction
DZMM - 13 January 2002

Government Body in S&T has new Chief
Manila Bulletin - 14 January 2002

Sambong Tablets/ Forte
DZEM - 4 February 2002

PCHRD
DZRB - 28 February 2002

PCHRD Anniversary, Medicinal Plants
Radio: Damayan - 4 March 2002

PCHRD Anniversary
Radio: Bago Yan Ah - 10 March 2002

Phytomedicines from Pascual Laboratories
Manila Bulletin - 14 March 2002

Street children risk death from SSDS
Manila Bulletin - 8 April 2002

Street children
DZRB - 9 April 2002

Lagundi, sambong, ampalaya,
WOW, UCLA doctors
Philippine Star - 3 June 2002

NSTW
DZRM - 16 June 2002

Lagundi, sambong in UCLA
Philippine Daily Inquirer - 5 June 2002

DOST Media Awards
Manila Bulletin - 30 July 2002

R&D on Health
Today Newspaper - 24 August 2002

Intestinal Capillariasis, (deadly parasites in
your favorite food)
Philippine Daily Inquirer - 24 August 2002

Local Technology Centers to Establish
Remote Links
Business World newspaper - 27 August 2002

Bisa ng Gamot (Halamang Gamot)
Taliba - September 4, 2002

Saving Tumor-affected bones
Philippine Daily Inquirer - 7 September 2002

Radio interview
OHRA Winner
DZRB, October 5, 2002

DZMM Radio Interview
OHRA Winner
October 13, 2002

Meet on AIDS
Seek to set guidelines vs disease
Philippine Daily Inquirer - October 16, 2002

UP Manila 20 years in the pages of History
Today - October 17, 2002

Lagundi Ascof Forte
Philippine Daily Inquirer - October 21, 2002

Health Journals Now Online
Philippine Daily Inquirer - October 30, 2002

Jewel Award gives Medicinal Plants Study
Manila Bulletin - December 16, 2002

Bisa ng Gamot (Halamang Gamot)
Taliba - September 4, 2002

Saving Tumor-affected bones
Philippine Daily Inquirer - 7 September 2002

Radio interview
OHRA Winner
DZRB, October 5, 2002

DZMM Radio Interview
OHRA Winner
October 13, 2002

Meet on AIDS
Seek to set guidelines vs disease
Philippine Daily Inquirer - October 16, 2002

UP Manila 20 years in the pages of History
Today - October 17, 2002

Lagundi Ascof Forte
Philippine Daily Inquirer - October 21, 2002

Health Journals Now Online
Philippine Daily Inquirer - October 30, 2002

Jewel Award gives Medicinal Plants Study
Manila Bulletin - December 16, 2002

Bisa ng Gamot (Halamang Gamot)
Taliba - September 4, 2002

Saving Tumor-affected bones
Philippine Daily Inquirer - 7 September 2002

Radio interview
OHRA Winner
DZRB, October 5, 2002

DZMM Radio Interview
OHRA Winner
October 13, 2002

Meet on AIDS
Seek to set guidelines vs disease
Philippine Daily Inquirer - October 16, 2002

UP Manila 20 years in the pages of History
Today - October 17, 2002

Lagundi Ascof Forte
Philippine Daily Inquirer - October 21, 2002

Health Journals Now Online
Philippine Daily Inquirer - October 30, 2002

Jewel Award gives Medicinal Plants Study
Manila Bulletin - December 16, 2002
{mospagebreak title=IV Keeping the Human Resource Active and Productive}
IV. Keeping the Human Resource Active and Productive

Course on Meta-Analysis Held

To develop the research capability of health professionals, we sponsored a course on meta-analysis last July 25-27 2002 at the University of the Philippines College of Public Health (UP-CPH) auditorium. Titled "Meta-Analysis in Medical Research," the three-day course was spearheaded by the Department of Epidemiology and Biostatistics (DEBS) of UP-CPH. The lecture was given by Dr. Dankmar Böhning, a world-renowned epidemiologist and biostatistician from Berlin-Humboldt University. Dr. Böhning discussed the types and designs of meta-analysis as well as methodological issues and recent developments in this area.

One hundred eleven (111) participants including those from Universiti Kebangsaan Malaysia and Myanmar attended. Local participants included representatives from hospitals, academic institutions, private and government organizations, pharmaceutical industries, and the Department of Health (DOH).

The Cancer Genetics Project:
Genetic Polymorphisms as
Biomarkers for Cancer Risk

Co-funded by PCHRD and the National Institutes of Health (NIH), the Institute of Human Genetics (IHG), NIH is presently conducting a molecular epidemiology study on the possible association between specific genetic polymorphism and cancer risk.

Current data suggests that age, sex, ethnicity and environmental exposure, maternal risk factors such as Ras and p53 mutations and gene to gene interactions must be considered to accurately assess the relationship between genetic polymorphism and cancer risk. By identifying high-risk individuals, the identified "at-risk genotypes" will serve as markers for cancer susceptibility. Also, better characterization of these gene-environment interactions in relation to carcinogenesis will play a vital role in developing health campaigns and cancer preventive methods.


Biomedical Devices Development Program, Phase 2

In 1998, we funded the procurement of the Instron Universal Testing Machine (UTM) model needed for the 5-Year Research and Development Program on Biomedical Devices headed by Dr. Rafael C. Bundoc of the Department of Orthopedics in UP-PGH. This five year program was completed in two years. In 2001, we approved the funding of the equipment needed for the Phase-2 of the program----the Establishment of the Gait Analysis Laboratory. This laboratory will serve in the analysis of human walking (gait) patterns, needed for preventing, treating and rehabilitating patients with leg (gait) problems.

The project officially began its implementation in 2002 and is expected to be completed in 2004.

2002 Outstanding Health Research Awardees

This year, ten nominations compete for the Outstanding Health Research Award (OHRA). For the first time, two researches for one category were found equally deserving for the award---all of equal scientific quality and equally responsive to the health concerns of the country.

The 2002 OHRA awardees were the following: The St. Luke's Dengue Research Program and Dr. Wang for his clinical work on Extremity Tumors, Limb Salvage Surgeries and Bone Transplantation for the Biomedical Research Category and the Helminthiasis Group for the Health system development category.

The St. Luke's Dengue Research Program was awarded for its dedication in developing diagnostic reagents and kit for dengue fever detection. They are also cited for their efforts to transfer the technology and initiate the development of an infrastructure for monitoring dengue cases and crisis management outbreak within the sentinel sites of the Department of Health (DOH).

Dr. Edward Wang's research work on the other hand was cited for providing an alternative to amputations and limb loss mostly due to bone cancer and bone transplants using allografts and limb saving surgeries. Dr. Wang's research resulted to a paradigm shift among doctors and patients regarding cancers of the extremities (arms and leg).

The Helminthiasis Study Group (HSG) was cited for its research on the widespread occurrence of death among children due to soil transmitted helminthiasis (intestinal worm infections) and its implication on the nutritional status and mental health on children. HSG's work on paragonimiasis (long fluke disease) assisted in preventing misdiagnosis of pulmonary tuberculosis (PTB) among infected patients since these two diseases have similar symptoms especially on chronic cough, and hemoptysis (coughing up of blood), which frequently confuse the diagnosis.

OHRA is awarded every two years to encourage researchers to exert efforts in realigning their research outputs into addressing the health needs of the Filipino people. The Award comes in two categories, in which, a cash price of P500, 000 pesos and a trophy were given per category.

PCHRD Scholarship and Thesis Assistance Program

This year, we funded five new PCHRD scholars (4 PhD/Dr PH; 1 MS) and three new thesis/dissertation grantees (2 PhD; 1 MS).

Out of the 46 on-going PCHRD scholars, five (4 MS; 1 PhD) graduated; while out of the 16 ongoing thesis/dissertation grantees, seven have completed (1 PhD; 6 MS) their papers.

Three scholars from Mindanao were supported: two from Davao Medical School Foundation (DMSF) and one from Central Mindanao State University (MSU) in Bukidnon.

PCHRD Research Fellowship Program

Of the three research fellows, one research fellow from Bicol Medical Center completed the implementation of the project entitled, "Assessment of the Health Effects of Chronic Solvent Abuse among Street children in Metro Manila" and presented the results of the said project in a press conference held last April 5,2002 at UP-NIH, Pedro Gil, Manila.

Short-term Training Program

A total of 9 training courses on basic research methods were conducted to enhance research skills of 300 medical faculty and staff of selected health research institutions.

Regional Research Funds

In line with the principle of equity in research, we provided funding assistance to five new research apprenticeship projects to encourage beginning researchers from the regions to be involved in health research. Out of the 39 on-going research apprenticeship projects, 19 had been completed.

Equity in Research - the Regions

The Regional Health Research and Development Committees in Regions 1,6,7,8 and 11 continued to undertake programs which were aimed to develop research interest and enhance research capabilities in the region through PCHRD's support.

Through the twinning program, a mechanism that enables centers of excellence based in Metro Manila to work with region-based institutions, the following twins undertook collaborative research work: University of the Philippines-College of Public Health (UP-CPH) and Ago-Bicol Christian College of Medicine; University of Santo Tomas (UST) Faculty of Medicine and Surgery and Angeles University Foundation; Far Eastern University-Dr. Nicanor Reyes Memorial Foundation (FEU-NRMF) and St. Louis University; Cebu Institute of Medicine and West Visayas State University. Ten research projects of five regional institutions were presented in a research forum held at the St. Louis University last November 30, 2002.


In Mindanao, a regional research forum was conducted last February 9, 2002 to disseminate and use the results of two completed researches from Xavier University's Dr. Jose P. Rizal College of Medicine. The forum was well-participated by the city health council officials of Cagayan de Oro, council of deans in Region 10 and directors of hospitals.

Profiles

Ma. Cristina Romero Ramos
PCHRD Fellow, 1998

Maria Cristina Romero Ramos received the PCHRD Research Fellowship grant for her project, 'Saponin as Booster of the Immune System' in 1998. At present, she works as an Assistant Professor with the University of Santo Tomas (UST) teaching Biochemistry and handling thesis students.

She also works as Research Assistant with UST's Research Center for Natural Sciences, where, she determines the immunomodulating property of natural products by performing assay on apoptosis and releases of cytokines; maintains cancer cell lines at the tissue culture laboratory and assists on the supervision of undergraduate students in the conduct of their research work.

To date, she has presented over 10 scientific papers in the country and published, in both local and international journals, three research articles. She also received several grants and awards among which are: the Deutscher Akademischer Austauschdiens (DAAD) "Sandwich Programme" Scheme at Heinrich-Heine-Universität in Dusseldorf, Germany; three months training grant from the British Council at the University of Strathclyde in Glasgow, Scotland in 1998; and a scholarship grant from the Philippine Council for Advanced Science and Technology (PCASTRD) for her MS in Chemistry in 1989-1991. She also won 2nd place for her entry, 'Killing cancer cells softly,' in PCHRD's 9th Scientific Poster Exhibit Contest.

Maria Cristina Ramos is also presently pursuing her doctorate degree in Chemistry at UST.

@ PCHRD Homebase

Our Human Resource

PCHRD will not be able to carry out its countless tasks and responsibilities without the concerted effort of 70 staff members, which, for this year, is composed of 41 technical, and 29 non-technical personnel.

To enhance the efficiency and quality in rendering our services, PCHRD sent 21 staff to training courses and seminars related to their profession. This gave them an opportunity to update their knowledge on new developments in their respective fields and improve productivity.

We also encouraged our staff to pursue advanced studies to further hone their knowledge and skills. One of our staff joined the ranks of our 16 masters and doctorate degree holders this year. Four are currently pursuing masters' degree and one a doctoral degree.

ar2002 financial report.jpg


APPENDICES


PCHRD SCHOLARS for CY 2002
(Sending Institution)

Completed

Doctoral Degree

Dr. Wilfredo Vendivil
PhD Biological Sciences
National Museum

Master's Degree

Dr. Elinor Gumila
MSPH Physiology
FEU-NRMF

Dr. Jose Navarro
MS Clinical Epidemiology
UST Faculty of Med and Surgery

Dr. Fideta Dico
MSPH Microbiology
Regional Health Office No. VIII

Dr. Lucila Perez
MS Clinical Epidemiology
MCU-FDTMF

New Scholars for SY 2002-2003

Doctoral Degree

Ms. Marilyn Crisostomo
PhD Statistics
UP College of Public Health

Dr. Edgardo Gonzaga
Dr.PH Medical Microbiology
Western Visayas Sanitarium

Ms. Razel Kawvono
Dr.PH Medical Microbiology
San Lazaro Hospital

Ms. Ligaya Picazo
Dr.PH Medical Microbiology
RITM

Master's Degree

Ms. Ma. Grace Rosales
MS Biostatistics
MCU-FDTMF


THESIS/ DISSERTATION GRANTEES


Completed

Shirley L. Caballero
University of Perpetual Help-Rizal
Degree: PhD Chemistry - DLSU
Title of Dissertation:
"Mushroom Metabolites as Potential Medicinal Agents and their Chemical Transformation"

Corine Lei Manangan
Angeles University Foundation
Degree: MS Microbiology- UST
Title of Thesis:
"Sorbitol-coconut Water Agar Medium for the Initial Isolation of Escherichia coli 0157:H7"

Ma. Hanshella Resurreccion-Magno
Institute of Chemistry- UP Diliman
Degree: MS Chemistry
Title of thesis:
"The anti-diabetic constituent of Syzygium samarangense Blume Leaves: Its Isolation, Purification and Structure Characterization"

Pilar de la Sena
MSU-IIT
Degree: MS Chemistry - MSU IIT
Title of Thesis:
"Bioactivity-guided isolation and Partial characterization of Metabolites from the Marine sponge Thorecta sp."

Phoebe Espinas
National Museum
Degree: MS Biological Sciences- UST
Title of Thesis:
"The Ethnomedicinal Plants of the Abellen Ayta of Tarlac"

Fern Ann G. Ramo
Silliman Univewrsity
Degree: MPH- Silliman University
Title of Thesis:
"A cost-benefit Analysis of the Directly Observed Treatmetn Short Course (DOTS) TB Program in the District of Bindoy, Negros Oriental in 1998 - 2000"

Cecile Leah Tiangson
UP College of Home Economics
Degree: MS Nutrition- UP Diliman
Title of Thesis:
"Relation of Diet and Income to the Docosahexaenoic Acid (DHA) Level in the Breast Milk of Some Filipino Women"


On-Going

Nina Castillo-Carandang
UPManila- Clinical Epidemiology Unit
Degree: PhD Medical Anthropology - University of Amsterdam
Title of Dissertation:
"Household & Community Responses to Fever and Perceived Malaria in an Endemic Philippine Village"

Teresita A. Tamayo
Bulacan State University
Degree: PhD Chemistry- UPDiiman
Title of dissertation:
"Chiral Separation of Ofloxacin Based on MIP"

Bella Panlillo
Angeles University Foundation
Degree: PHD Chemistry-UST
Title of Dissertation:
Isolation and Structural Elucidation of the Antitubercular Constituents from Momordica charantia Linn."

Tereza Paz G. Pascual, MD
DLSU- Dasmarinas, Cavite
Degree: MS Clinical Epidemiology- UPCEU
Title of Thesis:
"The Impact of Multi-faceted Educational Strategy on Improving practice Behavior Among Otolaryngologists in the treatment of Chronic Otitis Media with Effusion in Children and Chronic Suppurative Otitis Media in Adults"

Pura Alma D. Labis
MSU IIT
Degree: MS Social Science-DLSU
Title of Thesis:
"Reproductive Experiences of Second Wives of Polygamous Marriages in Iligan City and Lanao del Norte"

Ruby Raterta
PCIERD
Degree: MS Biological Sciences-UST
Title of Thesis:
"Composition and Fermentability Characteristics of Selected Legumes as a Source of Dietary Fiber"

New Grantees

Jose A. Mallari
MCU
Degree: PhD Biological Scieces-UST
Title of Dissertation:
"Production of Biodegradable Polybeta-hydroxybutarate from Sugarcane Molasses and Sulphite Waste Liquors by Batch and Fed-batch Fermentation"

Elizabeth I. Olarte
DMMSU- La Union
Degree: PhD Biological Sciences- UPDiliman
Title:
"In vitro anti-tumor and in vivo anti-teratogenic activities of the anthraquinones from Cassia alata L. leaves"


Marilym Rimando
UST-RCNS
Degree: MS Biological Sciences-UST
Title of Thesis:
"Cytogenetics and Molecular Detection of Chromosomal Aberrations and FusionGenes in Acute Lymphoblastic Leukemia (ALL) among Filipinos"

RESEARCH FELLOWSHIP PROGRAM GRANTEES


Completed


Janeta F. Sacbibit, MD
Sending Institution: Bicol Medical Center
Host Institution /Scientist: NPCIS-UPPGH/ Dr. Lynn Panganiban
Title of Project:
"Assessing the Health Effects of Chronic Solvent Abuse Among Streetchildren in Metro Manila"

On-going

Sheila M. de Jesus
Sending Institution: UST-College of Science
Host Institution/Scientist: UST-RCNS/ Dr. Gloria DC Bernas
Title of Project:
"An Evaluation of Filipino Hemophiliacs: Molecular Approach"

Danilo Villamangca, MD
Sending Institution: Rizal Medical Center
Host Institutio/Scientist: NPCIS-UPPGH/ Dr. Irma Makalinao
Title of Project:
"A Randomized Double-blind Controlled Trial of the Efficacy and Safety of Lorazepam and Diazepam in the Treatment of Patients with Alcohol withdrawal at the UP-PGH Medical Center"

Imelda A. Dakis, MD
Sending Institution: UST Faculty of Medicine & Surgery
Host Institution/Scientist: UST-RCNS/ Dr. Gloria DC Bernas
Title of Project:
"Geneomic Survey of Chronic Schizoprenia and Bipolar Affective Disorder in Filipinos"



LIST OF TRAINING CONDUCTED


Training on Basic Research
February 4-8, 2002
Batangas Regional Hospital
(34 participants attended)

Training on Basic Research Methods
May 9-11, 2002
West Visayas State University (WVSU)
(26 participants attended)

Training on Basic Research Methods
May 14-16, 2002
Samar State Polytechnic College, Catbalogan, Samar
(25 participants attended)

Short-term Course on Anti-oxidants
April 3-6, 2002
University of Sto. Tomas-Research Center for Natural Sciences (UST-RCNS)
(21 participants attended)

Training on Meta Analysis for Health
July 25-27, 2002
University of the Philippines-College of Public Health (UP-CPH)
(110 participants attended)

Training on Data Analysis with Application
on Microcomputers
September 24-27, 2002
Center for Health Development, Palo, Leyte
(23 participants attended)

Training on Basic Research Methods
September 11-12; 18-19;
September 30-October 1, 2002
Divine Word Hospital
(24 participants attended)

Training on Basic Research Methods
October 2-4, 2002
Country Lodge, Maasin City, Leyte
(17 participants attended)

Seminar on Ethics in Research
November 8, 2002
Department of Health (DOH) Conference Room
Candahug, Palo, Leyte
(20 participants attended)

RESEARCH APPRENTISHIP PROJECTS*
For CY 2002

New


1. Factors Associated with Exclusive Breastfeeding of Infants up to 4th month

2. Lifestyle Characteristics Associated with Cardiovascular Disease Among Health Workers and Industrial Workers in Bicol Region

3. Documentation of the Practice Patterns in the Use of Indigenous Herbs in the Management of Hypertension, Diabetes Mellitus, Hypercholesterolemia and Tuberculosis in Cities of Cebu and Iloilo

4. Morbidity and Mortality Trends for the Year 2002: Towards the Development of a Hospital-Based Data Registry, Cebu City and Iloilo City (deferred implementation)

5. Identification of Common Disorders Associated with the Common Chief Complaints of Patients Admitted in Tertiary Hospitals in Cebu City and Iloilo City, Jan. 2002-Dec. 2002 (deferred implementation)

On-going

1. Safety, Efficacy and Quality Studies on Selected Herbal Medicinal Products in Davao City

2. The Accuracy and Reliability of Rural Health Units Microscopic laboratory Team in the Detection of Malarial Parasites

3. Community Based Approached in the Control of Schistosomiasis in Newly Discovered Endemic areas

4. Randomized Clinical Trial Between Akapulko (Cassia alata) extract and Cotrimoxazole Cream 1% in the Treatment of Otomycosis

5. The Comparison of the Snail Infection Rate Before and After Mass Treatment of Human Population in Selected Endemic Barangays of Leyte


6. Prevalence of Dental Fluorosis Among the Residents of Poblacion, Bato, Leyte

7. Documentation of Indigenous Practices for Snake Bites in Northern Samar

8. Factors Associated with Acute Renal Failure of the Patients of Three Tertiary Hospitals in Legaspi City

9. Prevalence Study of Filariasis in Misamis Occidental

10. Descriptive Study of a Mass Pap Smear Reproductive Women in Cagayan de Oro

11. Efficacy of Commercial Sponge Filters in Improving Tap Water Potability in Dagupan City

12. Predisposing Factors of Mental Illness Among Psychiatric Patients at Mariano Marcos Memorial Hospital and Medical Center

13. Nosocomial Infections in Region 1

14. Prevalence of Clinically Significant Depressive Symptoms Using Beck Inventory Among Students of AGO-BCCM



Completed


1. Prostate Specific Antigen (PSA) Measurement in Asymptomatic Men with Equivocal Digital
Rectal Examination (DRE): Its Impact in Early Diagnosis of Prostate Cancer

2. Determination of the Prevalence of Iodine Deficiency and Correlationof Palpatory Determination of Thyroid Size with Ultrasonography in the school-aged population in a Barangay in Baguio City

3. Factors Associated with Anemia in Pregnant and the Relationship of Anemia to Low Birth Weight

4. KAP of the Indigenous Tribes of Albay and Camarines Sur on the Use of Medicinal Plants

5. The Effect of Short-term Steroid Therapy on the Tuberculin Reactivity of Patients (1-5 y/o) with Bronchial Asthma Suspected with Tuberculosis

6. KAP of Rural-Based Physicians on National Consensus of Tuberculosis Management

7. In vitro-effect of Luya Extract, Sampaloc Leaf and Saluyot Leaf Decoction on MTB

8. Hemoglobin Levels of Pre-school Children at High Altitude

9. A Survey on the Socio-demographic Profile of Physicians in Angeles City

10. Demographic Characteristics of Patients Admitted at Angeles University Foundation Medical Center in a 5-year Period

11. Knowledge, Personal and Work Related Characteristics: Its Association to Attitudes of
Nurses on HIV/AIDS (Reg. 6)

12. Chemical and Antitubular Studies of Morinda Citrifolia Linn (Noni) Fruit

13. The Epidemiology of Child Abuse in the City of Iloilo from 1995-2000

14. Preliminary Study on the Potability of Water in Selected Public Elementary Schools in Iloilo City, Philippines

15. A Cross-sectional Study of the Elderly Population of Cagayan de Oro City, 2001: Their Quality of Life and the Factors Affecting It

16. Cost Effectiveness Analysis of Screening and Immunization of Hepatitis B Among High Risk Personnel in Selected Private Hospitals of Cagayan de Oro City, 2001

17. The Reliability of Daytime Peripheral Blood Smear Collection in the Diagnosis of Filariasis

18. Prevalence and Factors Associated with Hypertension in Biliran Province

19. Traditional Medicine Practitioners and Their Practices in Leyte

* Research Projects of beginning researchers in the regions

LIST OF R&D PROJECTS


Completed

Evidence-Based Clinical Practice Guidelines on the Management of Breast Cancer
Department of Surgery
UP-PGH

Nutritional and Health Benefits of Coconut Flour
Food and Nutrition Research Institute, DOST

Metabolic Effects of Local Seaweeds Extract II: Lipid and Cholesterol Levels
College of Home Economics
UP Diliman

Continuing Projects

Pharmacologic/Toxicologic Studies of Philippine
Medicinal Plants
Department of Pharmacology, UP Manila

Mutagenicity, Clastogenicity, Anti-mutagenicity Potential of Drug Preparations from Philippine Medicinal Plants
College of Science, Department of Chemistry
UP Diliman

Establishment of Quality Control Bioassay Standard Procedures for Medicinal Plant Products
Department of Pharmacology
UP Manila

Dosage Forms from Medicinal Plant Constituents
College of Pharmacy
UP Manila

Clinical Screening and Validation Studies of Medicinal Plants Used in Traditional Folk Medicine in the Philippines
Department of Pharmacology, College of Medicine
UP Manila

Development of Appropriate Cultural Management Practices to Improve Yield and Quality of Selected Medicinal Plants
Department of Horticulture, College of Agriculture
UPLB

Ongoing Projects


A Sero-Epidemiologic Study of Hepatitis E Virus (HEV) Infection in the Philippines: A Community-based Cross-sectional Study
Liver Study Group
UP Manila

National Quality External Assessment of Clinical Laboratories in the Philippines
Phil. Council for Quality Assurance in Clinical Laboratories

Aspirin Dose Optimized in Non-cardioembolic Ischemic Stroke (ADONIS)
UP-PGH Department of Neurosciences

Development of National Guidelines on Periodic Health Examination
UP Department of Medicine Foundation

Generation of Humanized Single Gene-Encoded Antibodies with varied Effector Functions for Direct Use as Anti-Tumor Reagents and for the Production of Immunoliposomes: Desiclon (Proj 1-AMOR Program)
National Molecular Biology and Biotech
UP Diliman

Synthesis, physico-chemical and biological characterization of immunoliposomes for tumor cell surface Antigen directed delivery of anticancer drugs: Liprolong (Proj. 2 AMOR Program)
College of Medicine, FEU-Nicanor Reyes
Medical Foundation

Discovery and Development of Anti-cancer Drugs and other Agents for Immunoliosomoes-mediated Delivery to Breast Cancer Cells-PHILMARINA and PHILFLORA (Proj. 3.1 AMOR Program)
Marine Science Institute
UP Diliman

Discovery and Development of Anti-cancer Drugs and other Agents for Immunoliposomes-mediated Delivery to Breast Cancer Cells -PHILCELLS and GENEDELI (Proj. 3.2 AMOR Program)
NSRI
UP Diliman

Discovery and Development of Anti-cancer Drugs and other Agents for Immunoliposomes-mediated Delivery to Breast Cancer Cells-MOL-TARGET and VITROTOX (Proj. 3.3 AMOR Program)
Marine Science Institute
UP Diliman

New

Technology Generation and Transfer of Margarine Fortified with Vitamins A & B1, Iron, Iodine, Omega 3 and 6 Fatty Acids
FNRI, DOST